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In addition, ECM components like hyaluronan, tenascin-C and fibronectin bind to integrins and other receptors on immune cells, promoting an immunosuppressive environment that supports tumor progression [102]

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Somatostatin analogues are able to slow the rate of gastric emptying, slow small bowel transit, inhibit the release of gastrointestinal hormones, inhibit insulin secretion and inhibit postprandial vasodilation